Hemophilia of North Carolina

Hemophilia of North Carolina

Since 1977, in service to the people of North Carolina
affected by bleeding disorders

PO Box 70, Cary, NC 27512 — 1-800-990-5557 (toll free)

von Willebrand Disease


What is von Willebrand Disease?

Von Willebrand Disease (vWD) is a hereditary deficiency of von Willebrand factor in blood, occurring in 1% to 2% of the population. The factor is a protein that affects platelet function. Von Willebrand disease was first recognized in 1925 by Erik von Willebrand, a Finnish physician, who described a new type of bleeding disorder in inhabitants of the Aland Islands.

According to the National Hemophilia Foundation there are many variations of von Willebrand disease including:

  • Type I: Most common and mildest form of the disease. The von Willebrand factor levels are lower than normal and factor VIII levels may also be low.
  • Type II: The von Willebrand factor is abnormal.
  • Type III: Severe von Willebrand disease. A total absence of von Willebrand factor and low levels of factor VIII.
  • Pseudo von Willebrand disease: Platelets are defective rather than the von Willebrand factor.
  • Symptoms of von Willebrand disease include frequent or prolonged nosebleeds, easy bruising, bleeding gums, bleeding following dental work, and heavy menstrual periods.

References